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順天堂大学 大学院医学研究科 ゲノム・再生医療センター（再生医療研究室）Center of Genomic and Regeneration Medicineセンターについてメンバー研究内容業績業績業績業績2022Methods to Induce Small-Scale Differentiation of iPS Cells into Dopaminergic Neurons and to Detect Disease Phenotypes. Yamaguchi, A., Ishikawa, K.I., and Akamatsu, W. Methods Mol Biol 2022. 2549, 271-279. 10.1007/7651_2021_376. Involvement of kallikrein-PAR2-proinflammatory pathway in severe trastuzumab-induced cardiotoxicity Sasaki, R., Kurebayashi, N., Eguchi, H., Horimoto, Y., Shiga, T., Miyazaki, S., Kashiyama, T., Akamatsu, W., and Saito, M. Cancer Sci 2022. 113, 3449-3462. 10.1111/cas.15508. Increased excitability of human iPSC-derived neurons in HTR2A variant-related sleep bruxism Sarkar, A.K., Nakamura, S., Nakai, K., Sato, T., Shiga, T., Abe, Y., Hoashi, Y., Inoue, T., Akamatsu, W., and Baba, K. Stem Cell Res 2022. 59, 102658. 10.1016/j.scr.2022.102658. Autophagy promotes cell survival by maintaining NAD levels Kataura, T., Sedlackova, L., Otten, E.G., Kumari, R., Shapira, D., Scialo, F., Stefanatos, R., Ishikawa, K.I., Kelly, G., Seranova, E., et al. Dev Cell 2022. 57, 2584-2598.e2511. 10.1016/j.devcel.2022.10.008.Generation of three hiPSC clones from a Parkinson&＃8217;s disease patient with a heterozygous variant of VPS35 p.D620N Ishikawa, K.I., Ishiguro, M., Li, Y., Nishioka, K., Hattori, N., and Akamatsu, W. Stem Cell Res 2022. 60, 102739. 10.1016/j.scr.2022.102739. 2021Establishment of an in vitro model for analyzing mitochondrial ultrastructure in PRKN-mutated patient iPSC-derived dopaminergic neurons. Yokota, M., Kakuta, S., Shiga, T., Ishikawa, K.I., Okano, H., Hattori, N., Akamatsu, W., and Koike, M. Mol Brain 2021. 14, 58. 10.1186/s13041-021-00771-0.Developmental dysregulation of excitatory-to-inhibitory GABA-polarity switch may underlie schizophrenia pathology: A monozygotic-twin discordant case analysis in human iPS cell-derived neurons. Toritsuka, M., Yoshino, H., Makinodan, M., Ikawa, D., Kimoto, S., Yamamuro, K., Okamura, K., Akamatsu, W., Okada, Y., Matsumoto, T., et al. Neurochem Int 2021. 150, 105179. 10.1016/j.neuint.2021.105179.In vitro monitoring of HTR2A-positive neurons derived from human-induced pluripotent stem cells. Nakai, K., Shiga, T., Yasuhara, R., Sarkar, A.K., Abe, Y., Nakamura, S., Hoashi, Y., Kotani, K., Tatsumoto, S., Ishikawa, H., et al. Sci Rep 2021. 11, 15437. 10.1038/s41598-021-95041-3.Differentiation of Midbrain Dopaminergic Neurons from Human iPS Cells. Ishikawa, K.I., Nonaka, R., and Akamatsu, W. Methods Mol Biol 2021. 2322, 73-80. 10.1007/978-1-0716-1495-2_8.Generation of two iPSC lines from siblings of a homozygous patient with hearing loss and a heterozygous carrier with normal hearing carrying p.G45E/Y136X mutation in GJB2. Fukunaga, I., Oe, Y., Danzaki, K., Ohta, S., Chen, C., Iizumi, M., Shiga, T., Matsuoka, R., Anzai, T., Hibiya-Motegi, R., et al. Stem Cell Res 2021. 53, 102290. 10.1016/j.scr.2021.102290.2020Astrocytes Protect Human Dopaminergic Neurons from α-Synuclein Accumulation and Propagation. Tsunemi T, Ishiguro Y, Yoroisaka A, Valdez C, Miyamoto K, Ishikawa K, Saiki S, Akamatsu W, Hattori N, Krainc D. J Neurosci. 2020 Nov 4;40(45):8618-8628. doi: 10.1523/JNEUROSCI.0954-20.2020. Epub 2020 Oct 12.Generation of two induced pluripotent stem cell lines from PBMCs of siblings carrying c.235delC mutation in the GJB2 gene associated with sensorineural hearing loss. Fukunaga I, Shirai K, Oe Y, Danzaki K, Ohta S, Shiga T, Chen C, Ikeda K, Akamatsu W, Kawano A, Kamiya K. Stem Cell Res. 2020 Jul 19;47:101910. doi: 10.1016/j.scr.2020.101910.Identifying Therapeutic Agents for Amelioration of Mitochondrial Clearance Disorder in Neurons of Familial Parkinson Disease. Yamaguchi A, Ishikawa KI, Inoshita T, Shiba-Fukushima K, Saiki S, Hatano T, Mori A, Oji Y, Okuzumi A, Li Y, Funayama M, Imai Y, Hattori N, Akamatsu W. Stem Cell Reports. 2020 Jun 9;14(6):1060-1075. doi: 10.1016/j.stemcr.2020.04.011.A Cell-Based High-Throughput Screening Identified Two Compounds that Enhance PINK1-Parkin Signaling. Shiba-Fukushima K, Inoshita T, Sano O, Iwata H, Ishikawa KI, Okano H, Akamatsu W, Imai Y, Hattori N. iScience. 2020 May 22;23(5):101048. doi:10.1016/j.isci.2020.101048.Translational derepression of Elavl4 isoforms at their alternative 5&＃8242; UTRs determines neuronal development. Popovitchenko T, Park Y, Page NF, Luo X, Krsnik Z, Liu Y, Salamon I, Stephenson JD, Kraushar ML, Volk NL, Patel SM, Wijeratne HRS, Li D, Suthar KS, Wach A, Sun M, Arnold SJ, Akamatsu W, Okano H, Paillard L, Zhang H, Buyske S, Kostovic I, De Rubeis S, Hart RP, Rasin MR. Nat Commun. 2020 Apr 3;11(1):1674. doi: 10.1038/s41467-020-15412-8.Variants in saposin D domain of prosaposin gene linked to Parkinson&＃8217;s disease. Oji Y, Hatano T, Ueno SI, Funayama M, Ishikawa KI, Okuzumi A, Noda S, Sato S, Satake W, Toda T, Li Y, Hino-Takai T, Kakuta S, Tsunemi T, Yoshino H, Nishioka K, Hattori T, Mizutani Y, Mutoh T, Yokochi F, Ichinose Y, Koh K, Shindo K, Takiyama Y, Hamaguchi T, Yamada M, Farrer MJ, Uchiyama Y, Akamatsu W, Wu YR, Matsuda J, Hattori N. Brain. 2020 Apr 1;143(4):1190-1205. doi: 10.1093/brain/awaa064.BRUP-1, an intracellular bilirubin modulator, exerts neuroprotective activity in a cellular Parkinson&＃8217;s disease model. Kataura T, Saiki S, Ishikawa KI, Akamatsu W, Sasazawa Y, Hattori N, Imoto M. J Neurochem. 2020 Oct;155(1):81-97. doi: 10.1111/jnc.14997.Generation of the induced pluripotent stem cell (hiPSC) line (JUFMDOi004-A) from a patient with hearing loss carrying GJB2 (p.V37I) mutation. Fukunaga I, Shiga T, Chen C, Oe Y, Danzaki K, Ohta S, Matsuoka R, Anzai T, Hibiya-Motegi R, Tajima S, Ikeda K, Akamatsu W, Kamiya K. Stem Cell Res. 2020 Mar;43:101674. doi: 10.1016/j.scr.2019.101674.2019Mutations in CHCHD2 cause α-synuclein aggregation. Ikeda A, Nishioka K, Meng H, Takanashi M, Inoshita T, Shiba-Fukushima K, Li Y, Yoshino H, Mori A, Okuzumi A, Yamaguchi A, Nonaka R, Izawa N, Ishikawa KI, Saiki H, Morita M, Hasegawa M, Hasegawa K, Elahi M, Funayama M, Okano H, Akamatsu W, Imai Y, Hattori N. Hum Mol Genet. 2019 Oct 10Neuroprotective effects of memantine via enhancement of autophagy. Hirano K, Fujimaki M, Sasazawa Y, Yamaguchi A, Ishikawa KI, Miyamoto K, Souma S, Furuya N, Imamichi Y, Yamada D, Saya H, Akamatsu W, Saiki S, Hattori N. Biochem Biophys Res Commun. 2019 Oct 8;518(1):161-170.Cell-specific overexpression of COMT in dopaminergic neurons of Parkinson&＃8217;s disease. Kuzumaki N, Suda Y, Iwasawa C, Narita M, Sone T, Watanabe M, Maekawa A, Matsumoto T, Akamatsu W, Igarashi K, Tamura H, Takeshima H, Tawfik VL, Ushijima T, Hattori N, Okano H, Narita M. Brain. 2019 Jun 1;142(6):1675-1689.Increased Lysosomal Exocytosis Induced by Lysosomal Ca2+ Channel Agonists Protects Human Dopaminergic Neurons from α-Synuclein Toxicity. Tsunemi T, Perez-Rosello T, Ishiguro Y, Yoroisaka A, Jeon S, Hamada K, Rammonhan M, Wong YC, Xie Z, Akamatsu W, Mazzulli JR, Surmeier DJ, Hattori N, Krainc D. J Neurosci. 2019 Jul 17;39(29):5760-5772.Induced Pluripotent Stem Cells Reprogrammed with Three Inhibitors Show Accelerated Differentiation Potentials with High Levels of 2-Cell Stage Marker Expression. Nishihara K, Shiga T, Nakamura E, Akiyama T, Sasaki T, Suzuki S, Ko MSH, Tada N, Okano H, Akamatsu W. Stem Cell Reports. 2019 Feb 12;12(2):305-318. doi: 10.1016/j.stemcr.2018.12.018. Epub 2019 Jan 31.2018Zonisamide Administration Improves Fatty Acid β-Oxidation in Parkinson&＃8217;s Disease. Ueno SI, Saiki S, Fujimaki M, Takeshige-Amano H, Hatano T, Oyama G, Ishikawa KI, Yamaguchi A, Nojiri S, Akamatsu W, Hattori N. Cells. 2018 Dec 29;8(1).Soluble epoxide hydrolase plays a key role in the pathogenesis of Parkinson&＃8217;s disease. Ren Q, Ma M, Yang J, Nonaka R, Yamaguchi A, Ishikawa KI, Kobayashi K, Murayama S, Hwang SH, Saiki S, Akamatsu W, Hattori N, Hammock BD, Hashimoto K. Proc Natl Acad Sci U S A. 2018 Jun 19;115(25):E5815-E5823Rostrocaudal Areal Patterning of Human PSC-Derived Cortical Neurons by FGF8 Signaling. Imaizumi K, Fujimori K, Ishii S, Otomo A, Hosoi Y, Miyajima H, Warita H, Aoki M, Hadano S, Akamatsu W*, Okano H*. eNeuro. 2018 Apr 26;5(2).(* Corresponding Author)Down-regulation of ghrelin receptors on dopaminergic neurons in the substantia nigra contributes to Parkinson&＃8217;s disease-like motor dysfunction. Suda Y, Kuzumaki N, Sone T, Narita M, Tanaka K, Hamada Y, Iwasawa C, Shibasaki M, Maekawa A, Matsuo M, Akamatsu W, Hattori N, Okano H, Narita M. Mol Brain. 2018 Feb 20;11(1):6.Chemical decontamination of iPS cell-derived neural cell mixtures. Mao D, Chung XKW, Andoh-Noda T, Qin Y, Sato SI, Takemoto Y, Akamatsu W, Okano H, Uesugi M.Chem Commun (Camb). 2018 Feb 1;54(11):1355-1358.2017CHARGE syndrome modeling using patient-iPSCs reveals defective migration of neural crest cells harboring CHD7 mutations. Okuno H, Renault Mihara F, Ohta S, Fukuda K, Kurosawa K, Akamatsu W, Sanosaka T, Kohyama J, Hayashi K, Nakajima K, Takahashi T, Wysocka J, Kosaki K, Okano H.Elife. 2017 Nov 28;6. pii: e21114.Escape from Pluripotency via Inhibition of TGF-β/BMP and Activation of Wnt Signaling Accelerates Differentiation and Aging in hPSC Progeny Cells. Fujimori K, Matsumoto T, Kisa F, Hattori N, Okano H, Akamatsu W. Stem Cell Reports. 2017 Nov 14;9(5):1675-1691.Evidence that phosphorylated ubiquitin signaling is involved in the etiology of Parkinson&＃8217;s disease. Shiba-Fukushima K, Ishikawa KI, Inoshita T, Izawa N, Takanashi M, Sato S, Onodera O, Akamatsu W, Okano H, Imai Y, Hattori N.Hum Mol Genet. 2017 Aug 15;26(16):3172-3185Changeability of the fully methylated status of the 15q11.2 region in induced pluripotent stem cells derived from a patient with Prader-Willi syndrome. Okuno H, Nakabayashi K, Abe K, Ando T, Sanosaka T, Kohyama J, Akamatsu W, Ohyama M, Takahashi T, Kosaki K, Okano H.Congenit Anom (Kyoto). 2017 Jul;57(4):96-103.Generation of neural cells using iPSCs from sleep bruxism patients with 5-HT2A polymorphism. Hoashi Y, Okamoto S, Abe Y, Matsumoto T, Tanaka J, Yoshida Y, Imaizumi K, Mishima K, Akamatsu W, Okano H, Baba K.J Prosthodont Res. 2017 Jul;61(3):242-250.Differential X Chromosome Inactivation Patterns during the Propagation of Human Induced Pluripotent Stem Cells. Andoh-Noda T, Akamatsu W, Miyake K, Kobayashi T, Ohyama M, Kurosawa H, Kubota T, Okano H.Keio J Med. 2017 Mar 25;66(1):1-8.Assessment of Mitophagy in iPS Cell-Derived Neurons. Ishikawa KI, Yamaguchi A, Okano H, Akamatsu W. Methods Mol Biol. 2017 Mar 22.Differential gene expression profiles in neurons generated from lymphoblastoid B-cell line-derived iPS cells from monozygotic twin cases with treatment-resistant schizophrenia and discordant responses to clozapine. Nakazawa T, Kikuchi M, Ishikawa M, Yamamori H, Nagayasu K, Matsumoto T, Fujimoto M, Yasuda Y, Fujiwara M, Okada S, Matsumura K, Kasai A, Hayata-Takano A, Shintani N, Numata S, Takuma K, Akamatsu W, Okano H, Nakaya A, Hashimoto H, Hashimoto R. Schizophr Res. 2017 Mar;181:75-82.Brief exposure to small molecules allows induction of mouse embryonic fibroblasts into neural crest-like precursors. Takayama Y, Wakabayashi T, Kushige H, Saito Y, Shibuya Y, Shibata S, Akamatsu W, Okano H, Kida YS.FEBS Lett. 2017 Feb;591(4):590-602.Efficient induction of dopaminergic neuron differentiation from induced pluripotent stem cells reveals impaired mitophagy in PARK2 neurons. Suzuki S, Akamatsu W, Kisa F, Sone T, Ishikawa KI, Kuzumaki N, Katayama H, Miyawaki A, Hattori N, Okano H.Biochem Biophys Res Commun. 2017 Jan 29;483(1):88-93.Cochlear Cell Modeling Using Disease-Specific iPSCs Unveils a Degenerative Phenotype and Suggests Treatments for Congenital Progressive Hearing Loss. Hosoya M, Fujioka M, Sone T, Okamoto S, Akamatsu W, Ukai H, Ueda HR, Ogawa K, Matsunaga T, Okano H.Cell Rep. 2017 Jan 3;18(1):68-81.2016LNGFR+THY-1+ human pluripotent stem cell-derived neural crest-like cells have the potential to develop into mesenchymal stem cells. Ouchi T, Morikawa S, Shibata S, Fukuda K, Okuno H, Fujimura T, Kuroda T, Ohyama M, Akamatsu W, Nakagawa T, Okano H.Differentiation. 2016 Dec;92(5):270-280.Analysis of induced pluripotent stem cells carrying 22q11.2 deletion. Toyoshima M, Akamatsu W, Okada Y, Ohnishi T, Balan S, Hisano Y, Iwayama Y, Toyota T, Matsumoto T, Itasaka N, Sugiyama S, Tanaka M, Yano M, Dean B, Okano H, Yoshikawa T. Transl Psychiatry. 2016 Nov 1;6(11):e934.Modeling neurological diseases with induced pluripotent cells reprogrammed from immortalized lymphoblastoid cell lines. Fujimori K, Tezuka T, Ishiura H, Mitsui J, Doi K, Yoshimura J, Tada H, Matsumoto T, Isoda M, Hashimoto R, Hattori N, Takahashi T, Morishita S, Tsuji S, Akamatsu W*, Okano H*. Mol Brain. 2016 Oct 3;9(1):88. ] (* Corresponding Author)In vitro characterization of neurite extension using induced pluripotent stem cells derived from lissencephaly patients with TUBA1A missense mutations. Bamba Y, Shofuda T, Kato M, Pooh RK, Tateishi Y, Takanashi J, Utsunomiya H, Sumida M, Kanematsu D, Suemizu H, Higuchi Y, Akamatsu W, Gallagher D, Miller FD, Yamasaki M, Kanemura Y, Okano H. Mol Brain. 2016 Jul 19;9(1):70.Establishment of In Vitro FUS-Associated Familial Amyotrophic Lateral Sclerosis Model Using Human Induced Pluripotent Stem Cells. Ichiyanagi N, Fujimori K, Yano M, Ishihara-Fujisaki C, Sone T, Akiyama T, Okada Y, Akamatsu W, Matsumoto T, Ishikawa M, Nishimoto Y, Ishihara Y, Sakuma T, Yamamoto T, Tsuiji H, Suzuki N, Warita H, Aoki M, Okano H. Stem Cell Reports. 2016 Mar 16. Functional Neurons Generated from T Cell-Derived Induced Pluripotent Stem Cells for Neurological Disease Modeling. Matsumoto T, Fujimori K, Andoh-Noda T, Ando T, Kuzumaki N, Toyoshima M, Tada H, Imaizumi K, Ishikawa M, Yamaguchi R, Isoda M, Zhou Z, Sato S, Kobayashi T, Ohtaka M, Nishimura K, Kurosawa H, Yoshikawa T, Takahashi T, Nakanishi M, Ohyama M, Hattori N, Akamatsu W*, Okano H*. Stem Cell Reports. 2016 Feb 18. [Epub ahead of print] (* Corresponding Author)2015Controlling the Regional Identity of hPSC-Derived Neurons to Uncover Neuronal Subtype Specificity of Neurological Disease Phenotypes. Imaizumi K, Sone T, Ibata K, Fujimori K, Yuzaki M, Akamatsu W*, Okano H*. Stem Cell Reports. 2015 Dec 8;5(6):1010-22.Investigation of the fatty acid transporter-encoding genes SLC27A3 and SLC27A4 in autism. Maekawa M, Iwayama Y, Ohnishi T, Toyoshima M, Shimamoto C, Hisano Y, Toyota T, Balan S, Matsuzaki H, Iwata Y, Takagai S, Yamada K, Ota M, Fukuchi S, Okada Y, Akamatsu W, Tsujii M, Kojima N, Owada Y, Okano H, Mori N, Yoshikawa T. Sci Rep. 2015 Nov 9;5:16239.I2020T mutant LRRK2 iPSC-derived neurons in the Sagamihara family exhibit increased Tau phosphorylation through the AKT/GSK-3β signaling pathway. Ohta E, Nihira T, Uchino A, Imaizumi Y, Okada Y, Akamatsu W, Takahashi K, Hayakawa H, Nagai M, Ohyama M, Ryo M, Ogino M, Murayama S, Takashima A, Nishiyama K, Mizuno Y, Mochizuki H, Obata F, Okano H. Hum Mol Genet. 2015 Sep 1;24(17):4879-900.Differentiation of multipotent neural stem cells derived from Rett syndrome patients is biased toward the astrocytic lineage. Andoh-Noda T, Akamatsu W*,, Miyake K, Matsumoto T, Yamaguchi R, Sanosaka T, Okada Y, Kobayashi T, Ohyama M, Nakashima K, Kurosawa H, Kubota T, Okano H*,. Mol Brain. 2015 May 27;8:31 (* Corresponding Author)Utility of Scalp Hair Follicles as a Novel Source of Biomarker Genes for Psychiatric Illnesses. Maekawa M, Yamada K, Toyoshima M, Ohnishi T, Iwayama Y, Shimamoto C, Toyota T, Nozaki Y, Balan S, Matsuzaki H, Iwata Y, Suzuki K, Miyashita M, Kikuchi M, Kato M, Okada Y, Akamatsu W, Mori N, Owada Y, Itokawa M, Okano H, Yoshikawa T. Biol Psychiatry. 2015 Jul 15;78(2):116-25.2014The use of induced pluripotent stem cells to reveal pathogenic gene mutations and explore treatments for retinitis pigmentosa. Yoshida T, Ozawa Y, Suzuki K, Yuki K, Ohyama M, Akamatsu W, Matsuzaki Y, Shimmura S, Mitani K, Tsubota K, Okano H. Mol Brain. 2014 Jun 16;7:45.Involvement of ER stress in dysmyelination of Pelizaeus-Merzbacher Disease with PLP1 missense mutations shown by iPSC-derived oligodendrocytes. Numasawa-Kuroiwa Y, Okada Y, Shibata S, Kishi N, Akamatsu W, Shoji M, Nakanishi A, Oyama M, Osaka H, Inoue K, Takahashi K, Yamanaka S, Kosaki K, Takahashi T, Okano H. Stem Cell Reports. 2014 Apr 24;2(5):648-61.Reprogramming non-human primate somatic cells into functional neuronal cells by defined factors. Zhou Z, Kohda K, Ibata K, Kohyama J, Akamatsu W, Yuzaki M, Okano HJ, Sasaki E, Okano H. Mol Brain. 2014 Apr 3;7:24.Prenatal deletion of the RNA-binding protein HuD disrupts postnatal cortical circuit maturation and behavior. DeBoer EM, Azevedo R, Vega TA, Brodkin J, Akamatsu W, Okano H, Wagner GC, Rasin MR. J Neurosci. 2014 Mar 5;34(10):3674-86.Increased l1 retrotransposition in the neuronal genome in schizophrenia. Bundo M, Toyoshima M, Okada Y, Akamatsu W, Ueda J, Nemoto-Miyauchi T, Sunaga F, Toritsuka M, Ikawa D, Kakita A, Kato M, Kasai K, Kishimoto T, Nawa H, Okano H, Yoshikawa T, Kato T, Iwamoto K. Neuron. 2014 Jan 22;81(2):306-13.The RNA-binding protein HuD regulates autophagosome formation in pancreatic β cells by promoting autophagy-related gene 5 expression. Kim C, Kim W, Lee H, Ji E, Choe YJ, Martindale JL, Akamatsu W, Okano H, Kim HS, Nam SW, Gorospe M, Lee EK. J Biol Chem. 2014 Jan 3;289(1):112-212013A human Dravet syndrome model from patient induced pluripotent stem cells. Higurashi N, Uchida T, Lossin C, Misumi Y, Okada Y, Akamatsu W, Imaizumi Y, Zhang B, Nabeshima K, Mori MX, Katsurabayashi S, Shirasaka Y, Okano H, Hirose S. Mol Brain. 2013 May 2;6:19.Generation of human melanocytes from induced pluripotent stem cells.（Review Article) Ohta S, Imaizumi Y, Akamatsu W, Okano H, Kawakami Y. Methods Mol Biol. 2013;989:193-215.Enhanced aggregation of androgen receptor in induced pluripotent stem cell-derived neurons from spinal and bulbar muscular atrophy. Nihei Y, Ito D, Okada Y, Akamatsu W, Yagi T, Yoshizaki T, Okano H, Suzuki N. J Biol Chem. 2013 Mar 22;288(12):8043-52. Human induced pluripotent stem cell-derived ectodermal precursor cells contribute to hair follicle morphogenesis in vivo. Veraitch O, Kobayashi T, Imaizumi Y, Akamatsu W, Sasaki T, Yamanaka S, Amagai M, Okano H, Ohyama M. J Invest Dermatol. 2013 Jun;133(6):1479-88.2012以前Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue. Imaizumi Y, Okada Y, Akamatsu W, Koike M, Kuzumaki N, Hayakawa H, Nihira T, Kobayashi T, Ohyama M, Sato S, Takanashi M, Funayama M, Hirayama A, Soga T, Hishiki T, Suematsu M, Yagi T, Ito D, Kosakai A, Hayashi K, Shouji M, Nakanishi A, Suzuki N, Mizuno Y, Mizushima N, Amagai M, Uchiyama Y, Mochizuki H, Hattori N, Okano H. Mol Brain. 2012 Oct 6;5:35.Regeneration of the damaged central nervous system through reprogramming technology: basic concepts and potential application for cell replacement therapy.（Review Article) Matsui T, Akamatsu W, Nakamura M, Okano H. Exp Neurol. 2014 Oct;260:12-8.Derivation of induced pluripotent stem cells by retroviral gene transduction in mammalian species.(Review Article) Imamura M, Okuno H, Tomioka I, Kawamura Y, Lin ZY, Nakajima R, Akamatsu W, Okano HJ, Matsuzaki Y, Sasaki E, Okano H. Methods Mol Biol. 2012;925:21-48.Establishment of induced pluripotent stem cells from centenarians for neurodegenerative disease research. Yagi T, Kosakai A, Ito D, Okada Y, Akamatsu W, Nihei Y, Nabetani A, Ishikawa F, Arai Y, Hirose N, Okano H, Suzuki N. PLoS One. 2012;7(7):e41572.Neural stem cells directly differentiated from partially reprogrammed fibroblasts rapidly acquire gliogenic competency. Matsui T, Takano M, Yoshida K, Ono S, Fujisaki C, Matsuzaki Y, Toyama Y, Nakamura M, Okano H, Akamatsu W. Stem Cells. 2012 Jun;30(6):1109-19.RNA-binding protein HuD controls insulin translation. Lee EK, Kim W, Tominaga K, Martindale JL, Yang X, Subaran SS, Carlson OD, Mercken EM, Kulkarni RN, Akamatsu W, Okano H, Perrone-Bizzozero NI, de Cabo R, Egan JM, Gorospe M. Mol Cell. 2012 Mar 30;45(6):826-35.Modeling familial Alzheimer&＃8217;s disease with induced pluripotent stem cells. Yagi T, Ito D, Okada Y, Akamatsu W, Nihei Y, Yoshizaki T, Yamanaka S, Okano H, Suzuki N. Hum Mol Genet. 2011 Dec 1;20(23):4530-9.Generation of human melanocytes from induced pluripotent stem cells. Ohta S, Imaizumi Y, Okada Y, Akamatsu W, Kuwahara R, Ohyama M, Amagai M, Matsuzaki Y, Yamanaka S, Okano H, Kawakami Y. PLoS One. 2011 Jan 13;6(1):e16182.Suppression of Oct4 by germ cell nuclear factor restricts pluripotency and promotes neural stem cell development in the early neural lineage. Akamatsu W*, DeVeale B, Okano H, Cooney AJ, van der Kooy D*. J Neurosci. 2009 Feb 18;29(7):2113-24.A progressive and cell non-autonomous increase in striatal neural stem cells in the Huntington&＃8217;s disease R6/2 mouse. Batista CM, Kippin TE, Willaime-Morawek S, Shimabukuro MK, Akamatsu W, van der Kooy D. J Neurosci. 2006 Oct 11;26(41):10452-60.The RNA-binding protein HuD regulates neuronal cell identity and maturation. Akamatsu W*, Fujihara H, Mitsuhashi T, Yano M, Shibata S, Hayakawa Y, Okano HJ, Sakakibara S, Takano H, Takano T, Takahashi T, Noda T, Okano H*. (* Corresponding Author) Proc Natl Acad Sci U S A. 2005 Mar 22;102(12):4625-30.Nestin-EGFP transgenic mice: visualization of the self-renewal and multipotency of CNS stem cells. Kawaguchi A, Miyata T, Sawamoto K, Takashita N, Murayama A, Akamatsu W, Ogawa M, Okabe M, Tano Y, Goldman SA, Okano H. Mol Cell Neurosci. 2001 Feb;17(2):259-73.Mammalian ELAV-like neuronal RNA-binding proteins HuB and HuC promote neuronal development in both the central and the peripheral nervous systems. Akamatsu W, Okano HJ, Osumi N, Inoue T, Nakamura S, Sakakibara S, Miura M, Matsuo N, Darnell RB, Okano H. Proc Natl Acad Sci U S A. 1999 Aug 17;96(17):9885-90.業績ゲノム・再生医療センター（再生医療研究室）Center of Genomic and Regeneration Medicine アクセス プライバシーポリシー 〒113-8421　東京都文京区本郷2-1‐1 Copyright © JUNTENDO All rights reserved.